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Merck

1005004

USP

Acetazolamide

United States Pharmacopeia (USP) Reference Standard

Synonim(y):

5-Acetamido-1,3,4-thiadiazole-2-sulfonamide, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide

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2 G

2000,00 zł

2000,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C4H6N4O3S2
Numer CAS:
59-66-5
Masa cząsteczkowa:
222.25
NACRES:
NA.24
PubChem Substance ID:
329748132
UNSPSC Code:
41116107
MDL number:
MFCD00003105

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InChI

1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

SMILES string

CC(=O)Nc1nnc(s1)S(N)(=O)=O

InChI key

BZKPWHYZMXOIDC-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

acetazolamide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... CA1(759), CA12(771), CA2(760), CA4(762)

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Ta pozycja
A0100000BP904PHR1908
Acetazolamide United States Pharmacopeia (USP) Reference Standard

USP

1005004

Acetazolamide

Acetazolamide European Pharmacopoeia (EP) Reference Standard

A0100000

Acetazolamide

Acetazolamide British Pharmacopoeia (BP) Reference Standard

BP904

Acetazolamide

Acetazolamide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1908

Acetazolamide

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical

API family

acetazolamide

API family

acetazolamide

API family

acetazolamide

API family

acetazolamide

Gene Information

human ... CA1(759), CA12(771), CA2(760), CA4(762)

Gene Information

human ... CA1(759), CA12(771), CA2(760), CA4(762)

Gene Information

human ... CA1(759), CA12(771), CA2(760), CA4(762)

Gene Information

human ... CA1(759), CA12(771), CA2(760), CA4(762)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetazolamide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Acetazolamide Compounded Oral Suspension
  • Acetazolamide Extended-Release Capsules
  • Acetazolamide for Injection
  • Acetazolamide Tablets
Carbonic anhydrase inhibitor; increases cerebral blood flow.

Biochem/physiol Actions

Inhibits water permeability of membranes by interacting with aquaporins

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.
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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Klasa składowania

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Odwiedź Bibliotekę dokumentów

Emma V Low et al.
BMJ (Clinical research ed.), 345, e6779-e6779 (2012-10-20)
To assess the efficacy of three different daily doses of acetazolamide in the prevention of acute mountain sickness and to determine the lowest effective dose. Systematic review and meta-analysis. Medline and Embase along with a hand search of selected bibliographies.
A S Vagal et al.
AJNR. American journal of neuroradiology, 30(5), 876-884 (2009-02-28)
The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion. In patients with chronic steno-occlusive disease, the ability to maintain normal cerebral blood flow by reducing vascular resistance secondary to autoregulatory vasodilation
Neil D Ritchie et al.
Journal of travel medicine, 19(5), 298-307 (2012-09-05)
Acetazolamide has been reported to be effective in the prevention of acute mountain sickness (AMS). Our aim was to conduct a systematic review of randomized, placebo-controlled trials of acetazolamide in the prevention of AMS. Studies were identified by searching the
Bengt Kayser et al.
High altitude medicine & biology, 13(2), 82-92 (2012-06-26)
Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo
G Settakis et al.
European journal of neurology, 10(6), 609-620 (2003-12-04)
Pathologic processes affecting the brain vessels may damage cerebral vasodilatory capacity. Early detection of cerebral dysfunction plays an important role in the prevention of cerebrovascular diseases. In recent decades acetazolamide (AZ) has frequently been used for this purpose. In the
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