U4760

UR-AK57 dihydrochloride

≥98% (HPLC)

• Synonim(y): N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)-propyl]guanidine dihydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₂₉N₅O·2HCl
• Numer CAS: 902154-35-2
• Masa cząsteczkowa: 392.37
• NACRES: NA.77
• PubChem Substance ID: 329827632
• UNSPSC Code: 12352200
• MDL number: MFCD17215973
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CC(CC(=O)NC(=N)NCCCc1ncc[nH]1)C2CCCCC2
• InChI: 1S/C17H29N5O.2ClH/c1-13(14-6-3-2-4-7-14)12-16(23)22-17(18)21-9-5-8-15-19-10-11-20-15;;/h10-11,13-14H,2-9,12H2,1H3,(H,19,20)(H3,18,21,22,23);2*1H
• InChI key: IBBYQLOGMIDRMM-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine.

Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine. Histamine receptors are GPCRS and have long been therapeutic targets for allergic rhinitis. In brain, histamine receptors are targets for psychotherapeutics.

UR-AK57 is known to function as an effective, partial histamine H₁-receptor (H₁R) and H₂-receptor (H₂R) agonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UR-AK57 dihydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable