T8826

Terbinafine hydrochloride

• Synonim(y): trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₁H₂₅N · HCl
• Numer CAS: 78628-80-5
• Masa cząsteczkowa: 327.89
• NACRES: NA.85
• PubChem Substance ID: 329826887
• UNSPSC Code: 51302503
• MDL number: MFCD00145430

Właściwości

• assay: ≥98%
• Quality Segment: 200
• form: powder
• color: white to faint beige
• solubility: methanol: soluble 50 mg/mL
• antibiotic activity spectrum: fungi, yeast
• mode of action: enzyme | inhibits
• SMILES string: Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
• InChI: 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
• InChI key: BWMISRWJRUSYEX-SZKNIZGXSA-N

Opis

General description

Allylamine derivative.

Application

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Biochem/physiol Actions

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Disclaimer

The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H315,H319,H335,H410
• pcodes: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves