SRP5081

PTPRM (764-1452), GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in baculovirus infected Sf9 cells
• Próba: ≥70% (SDS-PAGE)
• Formularz: buffered aqueous glycerol solution
• masa cząsteczkowa: ~110 kDa
• numer dostępu NCBI: BC051651
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... PTPRM(5797)

Opis

Opis ogólny

PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.

Postać fizyczna

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable