SRP4809
Calretinin from mouse
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
Synonim(y):
CR, Calb2, Calretinin, calbindin 2
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About This Item
Kod UNSPSC:
12352202
pochodzenie biologiczne
mouse
rekombinowane
expressed in E. coli
Próba
≥90% (HPLC)
≥90% (SDS-PAGE)
Postać
solution
masa cząsteczkowa
~57 kDa
opakowanie
pkg of 5 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
zanieczyszczenia
endotoxin, tested
numer dostępu NCBI
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
mouse ... Calb2(12308)
Opis ogólny
Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
Działania biochem./fizjol.
Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.
Postać fizyczna
50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.
Rekonstytucja
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Dong G, et al.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
Christel CJ, et al.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Ayman Alzu'bi et al.
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Walter Blum et al.
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
Jonathan D Day-Brown et al.
The Journal of comparative neurology, 525(6), 1403-1420 (2016-03-15)
The tree shrew (Tupaia belangeri) striate cortex is reciprocally connected with the dorsal lateral geniculate nucleus (dLGN), the ventral pulvinar nucleus (Pv), and the claustrum. In the Pv or the dLGN, striate cortex projections are thought to either strongly "drive"
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