SRP3298

BMP-4 mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonim(y): BMP-2B, DVR4
• NACRES: NA.32
• UNSPSC Code: 12352202

Właściwości

• biological source: mouse
• recombinant: expressed in E. coli
• assay: ≥98% (HPLC), ≥98% (SDS-PAGE)
• form: lyophilized
• potency: 5-15 ng/mL ED₅₀
• mol wt: 23.8 kDa
• packaging: pkg of 10 μg
• impurities: <0.1 EU/μg endotoxin, tested
• UniProt accession no.: P21275
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... BMP4(12159)

Opis

General description

The gene BMP4 (bone morphogenetic protein 4) encodes a member of the TGFβ (transforming growth factor β) superfamily of intercellular signaling proteins. It is found to be expressed in the extraembryonic ectoderm and mesoderm. E. coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Application

Bone morphogenetic protein 4 (BMP4) mouse has been used as an agonist for activin A receptor 1 (ALK2) receptors to test the effects of ALK2 activation in cell death.

Biochem/physiol Actions

Bone morphogenetic protein 4 (BMP4) facilitates the the formation of allantois and primordial germ cell precursors in mouse embryo. It participates in hepatic specification in the early embryo. It is critical for the lens-inducing activity of optic vesicle in mouse embryo. BMP4 mediates atrioventricular septation of the mouse heart.

Physical form

Lyophilized from 10 mM Citric Acid.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in 10 mM Citric Acid to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H335
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable