SRP2148
EF1α, GST tagged human
recombinant, expressed in E. coli, ≥85% (SDS-PAGE)
Synonim(y):
CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, FLJ25721, LENG7, PTI1, eEF1A-1
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About This Item
Kod UNSPSC:
12352200
NACRES:
NA.26
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥85% (SDS-PAGE)
Postać
frozen liquid
masa cząsteczkowa
~77.3 kDa
opakowanie
pkg of 10 μg
stężenie
350 μg/mL
kolor
colorless to clear
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... EEF1A1(1915)
Działania biochem./fizjol.
The alpha subunit of elongation factor-1 (EEF1A) is involved in the binding of aminoacyl-tRNAs to 80S ribosomes. During the process, GTP is hydrolyzed into GDP. To perform this function, EEF1A has domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs. Also, EEF1A interacts with the beta subunit of EEF1 to exchange bound GDP for GTP. Multimolecular complexes involving the eukaryotic elongation factor 1A (eEF1A) have been suggested to play an important role in the channeling (vectorial transfer) of tRNA during protein synthesis HIV-1 matrix protein (MA) was found to interact with elongation factor 1-α (EF1α), an essential component of the translation machinery that delivers aminoacyl-tRNA to ribosomes. The interaction between MA and EF1α impairs translation in vitro, a result consistent with a previously proposed model in which inhibition of translation by the accumulation of Gag serves to release viral RNA from polysomes, permitting the RNA to be packaged into nascent virions. It has been identified that the translation elongation factor, eEF1A, and its guanine nucleotide exchange factor, eEF1Bβ, as translationally controlled tumor protein (TCTP)-interacting partners.
Postać fizyczna
Clear and colorless frozen liquid solution
Uwaga dotycząca przygotowania
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Cans, C., et al.
Proceedings of the National Academy of Sciences of the USA, 24, 13892-13897 (2003)
J H Brands et al.
European journal of biochemistry, 155(1), 167-171 (1986-02-17)
The primary structure of the alpha subunit of elongation factor 1 (EF-1 alpha) from human MOLT 4 cells was determined by cDNA sequencing. The data show that the conservation of the amino acid sequence is more than 80% when compared
A Cimarelli et al.
Journal of virology, 73(7), 5388-5401 (1999-06-11)
Human immunodeficiency virus type 1 (HIV-1) gag-encoded proteins play key functions at almost all stages of the viral life cycle. Since these functions may require association with cellular factors, the HIV-1 matrix protein (MA) was used as bait in a
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