SRP2034
Topo I (N1-197) (NTD) human
recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
Synonim(y):
TOPI
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.26
pochodzenie biologiczne
human
rekombinowane
expressed in insect cells
Próba
≥85% (SDS-PAGE)
Postać
frozen liquid
masa cząsteczkowa
~25.3 kDa
opakowanie
pkg of 5 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
stężenie
1000 μg/mL
kolor
clear colorless
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... TOP1(7150)
Działania biochem./fizjol.
Human DNA topoisomerase I is the best studied of the DNA topoisomerase family. It catalyzes the relaxation of both positive and negative supercoils without the requirement of energy. In addition to DNA replication and transcriptional activation, DNA topoisomerase I also plays a major role in pre-mRNA splicing, cell cycle and other gene regulatory pathways during cell growth and development. The N-terminal 214 amino acids of topoisomerase I comprise a highly charged N-terminal domain (NTD) involved in protein-protein interactions with a number of cellular proteins, including SV40 T antigen, nucleolin, SR proteins, p53 and other transcription factors.
Postać fizyczna
Clear and colorless frozen liquid solution
Uwaga dotycząca przygotowania
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
D Gai et al.
Journal of virology, 74(11), 5224-5232 (2000-05-09)
Topoisomerase I (topo I) is required for releasing torsional stress during simian virus 40 (SV40) DNA replication. Recently, it has been demonstrated that topo I participates in initiation of replication as well as in elongation. Although T antigen and topo
Yinghui Mao et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(3), 1235-1240 (2002-01-24)
The nonconserved, hydrophilic N-terminal domain of eukaryotic DNA topoisomerase I (topo I) is dispensable for catalytic activity in vitro but essential in vivo. There are at least five putative nuclear localization signals and a nucleolin-binding signal within the first 215
P Haluska et al.
Nucleic acids research, 26(7), 1841-1847 (1998-05-30)
We have attempted to identify human topoisomerase I-binding proteins in order to gain information regarding the cellular roles of this protein and the cytotoxic mechanisms of the anticancer drug camptothecin, which specifically targets topoisomerase I. In the course of this
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