Ludzka bromodomena zawierająca 3, znana również jako BRD3 lub RING3L (GenBank Accession No. NM_007371) aminokwasy 306 - 417 z N-końcowym tagiem HIS, MW = 14,1 kDa, wyrażona w systemie ekspresji E. coli.
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Molecular and cellular biology, 31(13), 2632-2640 (2011-05-11)
Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming clear that
Proceedings of the National Academy of Sciences of the United States of America, 108(22), E159-E168 (2011-05-04)
Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved
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