SRP0400

PRMT4 peptide, biotin

≥90% (HPLC)

• NACRES: NA.32
• UNSPSC Code: 12352202
• Assay: ≥90% (HPLC)
• Concentration: 400 μM

Właściwości

• assay: ≥90% (HPLC)
• form: aqueous solution
• packaging: pkg of 80 nmol
• concentration: 400 μM
• UniProt accession no.: Q86X55
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CARM1(10498)

Opis

General description

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

Application

Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.

Biochem/physiol Actions

Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

Physical form

Supplied in a TRIS-buffered solution.

Other Notes

200 μL at 400 μM, or 80 nmol. Sold as 80 nmol

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable