SML4055
UNC3230
≥98% (HPLC)
Synonim(y):
2-Anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide, 5-(cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
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Wzór empiryczny (zapis Hilla):
C17H20N4O2S
Numer CAS:
Masa cząsteczkowa:
344.43
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
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Pomoc techniczna
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Pozwól nam pomócInChI key
RZCNASHHHSKTGP-UHFFFAOYSA-N
SMILES string
O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1
assay
≥98% (HPLC)
form
powder
color
, White to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Powiązane kategorie
Biochem/physiol Actions
Inhibitor of phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C).
UNC3230 is a selective inhibitor of the lipid kinase phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C) with an IC50 of 41 nM. UNC3230 showed selectivity for PIP5K1C and PIP4K2C (phosphatidylinositol 5-phosphate 4-kinase, type II, gamma) and did not inhibit PIP5K1A or any of the other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 4,5-bisphosphate 3-kinases (PIK3s, also known as PI3Ks). UNC3230 lowered PIP2 levels in nociceptive dorsal root ganglia (DRG) neurons and had antinociceptive effects when injected intrathecally as well as peripherally into the hindpaw, indicating that either central or peripheral inhibition of PIP5K1C can reduce nociceptive responses.
UNC3230 is a selective inhibitor of the lipid kinase phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C) with an IC50 of 41 nM. UNC3230 showed selectivity for PIP5K1C and PIP4K2C (phosphatidylinositol 5-phosphate 4-kinase, type II, gamma) and did not inhibit PIP5K1A or any of the other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 4,5-bisphosphate 3-kinases (PIK3s, also known as PI3Ks). UNC3230 lowered PIP2 levels in nociceptive dorsal root ganglia (DRG) neurons and had antinociceptive effects when injected intrathecally as well as peripherally into the hindpaw, indicating that either central or peripheral inhibition of PIP5K1C can reduce nociceptive responses.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Brittany D Wright et al.
Neuron, 82(4), 836-847 (2014-05-24)
Numerous pain-producing (pronociceptive) receptors signal via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis. However, it is currently unknown which lipid kinases generate PIP2 in nociceptive dorsal root ganglia (DRG) neurons and if these kinases regulate pronociceptive receptor signaling. Here, we found that phosphatidylinositol
Yukino Kato et al.
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Andrey A Parkhitko et al.
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The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could lead to new approaches to treating
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