SML3930
SDM25N
≥98% (HPLC)
Synonim(y):
(4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, N-2-Methylallyl-noroxymorphindole, SDM 25N, SDM-25N, TU 753, TU-753, TU753
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Wzór empiryczny (zapis Hilla):
C26H26N2O3
Numer CAS:
Masa cząsteczkowa:
414.50
NACRES:
NA.77
UNSPSC Code:
12352200
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Pozwól nam pomócassay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Potent and highly selective delta-opioid receptor (DOR) antagonist.
SDM25N (TU753) is a potent and highly selective delta-opioid receptor (DOR) antagonist (δ/κ/μ Ki = 4.7 nM/3.8 μM/7.9 μM). SDM25N is also reported to inhibit Dengue virus (DENV) that restricts genomic RNA replication (EC50 = 1.9 μM using Hela DENV2 replicon cells) by targeting the viral NS4B protein.
SDM25N (TU753) is a potent and highly selective delta-opioid receptor (DOR) antagonist (δ/κ/μ Ki = 4.7 nM/3.8 μM/7.9 μM). SDM25N is also reported to inhibit Dengue virus (DENV) that restricts genomic RNA replication (EC50 = 1.9 μM using Hela DENV2 replicon cells) by targeting the viral NS4B protein.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
T Ullrich et al.
Bioorganic & medicinal chemistry letters, 11(21), 2883-2885 (2001-10-13)
In an effort to establish the importance of the N-(2-methylallyl) substituent in the noroxymorphone series, several derivatives have been synthesized, retaining that N-substituent and modifying the delta address moiety. A few compounds showed moderate binding affinity and selectivity for the
Koen W R van Cleef et al.
Antimicrobial agents and chemotherapy, 60(4), 2554-2557 (2016-02-10)
Despite the enormous disease burden associated with dengue virus infections, a licensed antiviral drug is lacking. Here, we show that the paracetamol (acetaminophen) metabolite AM404 inhibits dengue virus replication. Moreover, we find that mutations in NS4B that were previously found
Josue Jaramillo-Polanco et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(16), 3316-3328 (2022-03-09)
Opioid tolerance (OT) leads to dose escalation and serious side effects, including opioid-induced hyperalgesia (OIH). We sought to better understand the mechanisms underlying this event in the gastrointestinal tract. Chronic in vivo administration of morphine by intraperitoneal injection in male
Koen W R van Cleef et al.
Antiviral research, 99(2), 165-171 (2013-06-06)
Dengue virus (DENV) is an important human arthropod-borne virus with a major impact on public health. Nevertheless, a licensed vaccine or specific treatment is still lacking. We therefore screened the NIH Clinical Collection (NCC), a library of drug-like small molecules
Franck Touret et al.
Antiviral research, 168, 109-113 (2019-05-16)
Dengue fever is the most widespread of the human arbovirus diseases, with approximately one third of the world's population at risk of infection. Dengue viruses are members of the genus Flavivirus (family Flaviviridae) and, antigenically, they separate as four closely
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