SML3340

Sgl1 inhibitor Hit 1

≥98% (HPLC)

• Synonim(y): 4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol
• Wzór empiryczny (zapis Hilla): C₁₇H₂₂N₂O₃S
• Numer CAS: 1332191-15-7
• Masa cząsteczkowa: 334.43
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Właściwości

• InChI key: FXCZNKJONOHACS-UHFFFAOYSA-N
• SMILES string: COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Opis

Biochem/physiol Actions

Cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1)

Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable