SML3250

HIF-1α stabilizer 1a

≥98% (HPLC)

• Synonim(y): Bis[2-(2-pyridinyl-kN)phenyl-kC](4,7-dimethoxy-1,10-phenanthroline-kN1, kN10)iridium(III) hexafluorophosphate (1:1), Ir(III) complex 1a
• Wzór empiryczny (zapis Hilla): C₃₆H₂₈O₂IrN₄·PF₆
• Masa cząsteczkowa: 885.81
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Biochem/physiol Actions

Cell penetrant stabilizer of hypoxia-inducible factor-1α (HIF-1α)

HIF-1α stabilizer 1a, a cyclometalated iridium(III) complex, is a cell penetrant stabilizer of hypoxia-inducible factor-1α (HIF-1α) that binds to Von Hippel-Lindau (VHL) tumor suppressor and inhibits the VHL–HIF-1α interaction thereby preventing HIF-1α degradation. HIF-1α stabilizer 1a induces HIF-1α accumulation in cells and activates HIF-1α mediated gene expression. It significantly accelerates wound closure in both normal.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable