Glutor is a potent inhibitor of glucose uptake that targets glucose transporters GLUT1, -2, and -3. Inhibition of glucose uptake by glutor leads to upregulation of GLUT3 and GLUT1 expression. Glutor potently and selectively suppresses growth of a variety of cancer cell lines. Glutor and glutaminase inhibitor CB-839 synergistically inhibit tumor cell growth.
potent inhibitor of glucose uptake that targets glucose transporters GLUT-1, -2, and -3
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Cell chemical biology, 26(9), 1214-1228 (2019-07-16)
Cancer cells sustain growth by altering their metabolism to accelerated aerobic glycolysis accompanied by increased glucose demand and employ glutamine as additional nutrient source. This metabolic adaptation induces upregulation of glucose transporters GLUT-1 and -3, and simultaneous targeting of both
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