SML1644

MRT68921 dihydrochloride

≥98% (HPLC)

• Synonim(y): N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide dihydrochloride
• Wzór empiryczny (zapis Hilla): C₂₅H₃₄N₆O · 2HCl
• Numer CAS: 1190379-70-4
• Masa cząsteczkowa: 507.50
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825985
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C1)CCC2=C1C=CC(NC3=NC=C(C4CC4)C(NCCCNC(C5CCC5)=O)=N3)=C2.[H]Cl.[H]Cl
• InChI: 1S/C25H34N6O.2ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);2*1H
• InChI key: NLKPLTWKINJHCK-UHFFFAOYSA-N

Opis

Application

MRT68921 dihydrochloride has been used:

• as a specific inhibitor of Unc-51-like kinase 1 (ULK1) in SH-SY5Y neuroblastoma cells[1]
• as an inhibitor of ULK1 and ULK2 kinases in intrahepatic lymphocytes[2]
• as a ULK1 inhibitor to test its effect on attenuation of autophagosome accumulation in ubiquitin-specific peptidase 24 (USP24) knockdown containing human neuroglioma H4 cells[3]

Biochem/physiol Actions

MRT68921 is a cell penetrant, potent and specific inhibitor of ULK1 and ULK2 kinases in vitro, which reduces ULK1 activity in cells and blocks autophagy induction. MRT68921 blocks mTOR dependent autophagy.

MRT68921 is a cell penetrant, potent and specific inhibitor of ULK1 and ULK2 kinases in vitro.

MRT68921 is cytotoxic and acts on oxidative stress signals to kill cancer cells, making it an effective tumor therapy agent.[1]

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable