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Dokumenty

SML0742

Sigma-Aldrich

EUK-8

≥95% (HPLC)

Synonim(y):

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese, (Salen)manganese(III) chloride, Chloro(bis(salicylidene)ethylenediamine)manganese, Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese, EUK 8, Manganese(salen) chloride

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About This Item

Wzór empiryczny (zapis Hilla):
C16H14ClMnN2O2
Numer CAS:
53177-12-1
Masa cząsteczkowa:
356.69
Kod UNSPSC:
12352200
NACRES:
NA.77

Próba

≥95% (HPLC)

Postać

powder

warunki przechowywania

desiccated

kolor

, faint to very dark brown

rozpuszczalność

H2O: 1 mg/mL, clear

temp. przechowywania

−20°C

InChI

1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3

Klucz InChI

HBQGFROGWOHBAG-UHFFFAOYSA-K

Działania biochem./fizjol.

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Inne uwagi

air sensitive
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Samanta Do Amaral et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 21(4), 425-432 (2007-12-29)
The catalase mimetic complex Mn(III)-salen chloride (EUK8) was found to be pro-oxidant under low hydrogen peroxide concentrations. The increase in the fluorescence rate of the probe 1,2,3-dihydrorhodamine (DHR) in solution, as well as the carbonyl content of human serum albumin
M Ata Secilmis et al.
Acta pharmacologica Sinica, 29(6), 687-697 (2008-05-27)
The aim of this study was to investigate whether superoxide dismutase (SOD) enzymes and ascorbate play a role in the protection of the nitrergic relaxation against superoxide anion inhibition in the mouse duodenum. The effects of exogenous SOD, N,No-bis(salicylidene) ethylenediamine
Nirali Pandya et al.
Chirality, 24(12), 1063-1073 (2012-09-13)
We are reporting the synthesis, characterization, and calf thymus DNA binding studies of novel chiral macrocyclic Mn(III) salen complexes S-1, R-1, S-2, and R-2. These chiral complexes showed ability to bind with DNA, where complex S-1 exhibits the highest DNA
Sakineh Meftah et al.
Drug and chemical toxicology, 36(1), 9-18 (2012-01-24)
Increased levels of reactive oxygen species (ROS) play a vital role in the pathogenesis of various diseases. Thus, antioxidants would play pivotal roles in the therapy of ROS-induced diseases. Regarding this fact, in the present study, we compared the relative
Satoru Kawakami et al.
Circulation journal : official journal of the Japanese Circulation Society, 73(11), 2125-2134 (2009-09-15)
Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8. Presymptomatic heart/muscle-specific Mn-SOD-deficient mice (H/M-Sod2(-/-)) were treated with EUK-8 (30
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