Przejdź do zawartości
Merck

SML0564

PD153035 hydrochloride

≥98% (HPLC)

Synonim(y):

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868

Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.

Wybierz wielkość

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C16H14BrN3O2 · HCl
Numer CAS:
183322-45-4
Masa cząsteczkowa:
396.67
NACRES:
NA.77
PubChem Substance ID:
329825555
UNSPSC Code:
51111800
MDL number:
MFCD01074805
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Kluczowe dokumenty

Wyświetl całą dokumentację
Pomoc techniczna
Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.
Pozwól nam pomóc
Pomoc techniczna
Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.
Pozwól nam pomóc

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Cl.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

InChI

1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

InChI key

ZJOKWAWPAPMNIM-UHFFFAOYSA-N

Powiązane kategorie

Biochem/physiol Actions

PD153035 is an EGFR tyrosine kinase inhibitor.
PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Ta strona może zawierać tekst przetłumaczony maszynowo.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000404616
0000400154
0000400154
0000404616
0000122278

Nie widzisz odpowiedniej wersji?

Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

Wyszukaj dokument COA

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Rainelli B Koumangoye et al.
Molecular cancer, 12(1), 167-167 (2013-12-21)
The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-surface receptors to promote cellular processes
Amelia G Pérez et al.
Oncology reports, 44(4), 1649-1661 (2020-09-19)
Changes in protein levels in different components of the apical junctional complex occur in colorectal cancer (CRC). Claudin‑3 is one of the main constituents of tight junctions, and its overexpression can increase the paracellular flux of macromolecules, as well as
Naoya Hino et al.
Developmental cell, 53(6), 646-660 (2020-06-05)
During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission
Carlos Pardo-Pastor et al.
Science advances, 9(39), eadi1328-eadi1328 (2023-09-27)
EGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. While EGF ligand and mechanical inputs can activate EGFR-ERK signaling, the molecules linking mechanical force to this axis have remained mysterious. We previously found that stretch promotes mitosis via
Benjamin Toh et al.
PLoS biology, 9(9), e1001162-e1001162 (2011-10-08)
In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of selected, random mutations and thus would occur late in cancer progression. However, recent studies show
Wyświetl wszystkie powiązane dokumenty

Produkty

EGFR

Our company offers many products related to EGFR for your research needs.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Numer pozycji handlu globalnego

SKUNUMER GTIN
SML0564-5MG04061832963037
SML0564-25MG04061832963020

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej