Przejdź do zawartości
Merck
Wszystkie zdjęcia(1)

Dokumenty

SML0261

Sigma-Aldrich

SC66

≥98% (HPLC)

Synonim(y):

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(1)

About This Item

Wzór empiryczny (zapis Hilla):
C18H16N2O
Numer CAS:
871361-88-5
Masa cząsteczkowa:
276.33
Numer MDL:
MFCD05025493
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329825269

Próba

≥98% (HPLC)

Postać

powder

kolor

faintly yellow to dark yellow

rozpuszczalność

DMSO: ≥5 mg/mL (warmed)

temp. przechowywania

2-8°C

ciąg SMILES

O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

InChI

1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+

Klucz InChI

CYVVJSKZRBZHAV-UNZYHPAISA-N

Działania biochem./fizjol.

SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.
This page may contain text that has been machine translated.

Kod klasy składowania

13 - Non Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Rong Chen et al.
Oxidative medicine and cellular longevity, 2020, 6954764-6954764 (2020-04-08)
Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. C57BL/6J mice were subjected to unilateral IIR with or without IPO. After 45 min ischemia
Chao-Yu Loung et al.
Molecules (Basel, Switzerland), 24(18) (2019-09-22)
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells was determined and compared with the effect of
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
Yanan Kong et al.
Journal of cellular physiology, 234(11), 20801-20815 (2019-04-30)
In diabetes, the number of bone mesenchymal stem cells (MSCs) decreases and their differentiation is impaired. However, the exact mechanism is unclear. Patients with diabetes often experience sympathetic nerve injury. Norepinephrine (NE), a major mediator of the sympathetic nervous system
Camilla Olaisen et al.
Cellular signalling, 27(7), 1478-1487 (2015-03-24)
Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two known PCNA-interacting motifs, the
Wyświetl wszystkie powiązane dokumenty

Produkty

PKB/Akt

We offer many products related to PKB/Akt for your research needs.

PKB/Akt

Oferujemy wiele produktów związanych z PKB/Akt dla potrzeb badawczych.

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej