SML0151

CCT036477

• Synonim(y): α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine
• Wzór empiryczny (zapis Hilla): C₂₁H₁₈ClN₃
• Numer CAS: 305372-78-5
• Masa cząsteczkowa: 347.84
• NACRES: NA.77
• PubChem Substance ID: 329825199
• UNSPSC Code: 12352200
• MDL number: MFCD01831143
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥20 mg/mL (warm to 60°C)
• storage temp.: −20°C
• SMILES string: Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4
• InChI: 1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
• InChI key: IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Wnt β-catenin antagonist

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable