SML0009
AI-1
≥98% (HPLC)
Synonim(y):
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester, Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C13H12ClNO3
Numer CAS:
Masa cząsteczkowa:
265.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pomoc techniczna
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Pozwól nam pomócassay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
ClC(C1=C(N2C)C=CC=C1)=C(C(OCC)=O)C2=O
InChI
1S/C13H12ClNO3/c1-3-18-13(17)10-11(14)8-6-4-5-7-9(8)15(2)12(10)16/h4-7H,3H2,1-2H3
InChI key
XUJQDJGGHFNYDY-UHFFFAOYSA-N
Biochem/physiol Actions
AI-1 positively regulates antioxidant response element (ARE)-driven gene transcription through the activation of Nuclear factor E2-related factor 2 (Nrf2), an ARE-binding transcription factor.
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Kristina Stephens et al.
Nature communications, 10(1), 4129-4129 (2019-09-13)
Synthetic biology and metabolic engineering have expanded the possibilities for engineered cell-based systems. The addition of non-native biosynthetic and regulatory components can, however, overburden the reprogrammed cells. In order to avoid metabolic overload, an emerging area of focus is on engineering
Kyoko Hosohama-Saito et al.
PloS one, 11(1), e0147114-e0147114 (2016-01-23)
Capnocytophaga ochracea is present in the dental plaque biofilm of patients with periodontitis. Biofilm cells change their phenotype through quorum sensing in response to fluctuations in cell-population density. Quorum sensing is mediated by auto-inducers (AIs). AI-2 is involved in intercellular
Tiziana Fuoco et al.
Biomacromolecules, 21(1), 188-198 (2019-09-25)
The advancement of 3D printing technologies in the fabrication of degradable scaffolds for tissue engineering includes, from the standpoint of the polymer chemists, an urgent need to develop new materials that can be used as ink and are suitable for
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| SML0009-5MG | 04061833221501 |
| SML0009-25MG | 04061833221495 |