This product is not tested for solubility. However, Omadacycline has limited solubility in water and aqueous buffers. Other sources indicate this compound in soluble in DMSO up to 100 mg/mL and Ethanol up to 25 mg/mL. This information has not been validated. This product is intended for research use only; a Biopharmaceutics Classification System (BCS) classification is not applicable.
Przejdź do
SBR00042
Omadacycline
≥98% (HPLC)
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 761,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C29H40N4O7
Numer CAS:
Masa cząsteczkowa:
556.65
NACRES:
NA.76
UNSPSC Code:
41116107
MDL number:
761,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócQuality Segment
assay
≥98% (HPLC)
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
InChI
1S/C29H40N4O7/c1-28(2,3)12-31-11-14-10-17(32(4)5)15-8-13-9-16-21(33(6)7)24(36)20(27(30)39)26(38)29(16,40)25(37)18(13)23(35)19(15)22(14)34/h10,13,16,21,31,34,36-37,40H,8-9,11-12H2,1-7H3,(H2,30,39)/t13-,16-,21-,29-/m0/s1
InChI key
JEECQCWWSTZDCK-IQZGDKDPSA-N
General description
Omadacycline is an aminomethylcycline, a novel semisynthetic tetracycline-class antibiotic drug.(1)(2) It is distinguished from other tetracycline-class drugs like tigecycline and eravacycline at the C9 position with an aminomethyl substitution.(2)
Application
Mode of Action: Interferes with protein synthesis Antibiotic Activity Spectrum: Gram-negative bacteria and Gram-positive bacteria.
Biochem/physiol Actions
Omadacycline displays antimicrobial activities against a broad spectrum of organisms including Gram-positive, Gram-negative, anaerobic, and atypical bacteria.(3)(4) It inhibits bacterial protein synthesis by binding on the 30S subunit of the bacterial ribosome.(1)(2) Omadacycline is also effective against tetracycline efflux proteins in in vitro studies and protects against bacterial tetracycline resistance.(4) It has improved efficacy than other tetracycline drugs against acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired bacterial pneumonia (CABP).(1)(2)(5) In nonclinical and ex vivo studies, omadacycline displays a low potential for cardiovascular toxicity.(6)
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Ta pozycja | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description - | description ≥97% (LC/MS) |
| form powder | form powder | form powder or crystals | form powder |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum viruses | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-positive bacteria |
| storage temp. −20°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell membrane | interferes |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| assay ≥98% (HPLC) | assay - | assay 95.0-102.0% anhydrous basis | assay ≥98% (HPLC) |
signalword
Warning
hcodes
Hazard Classifications
Lact. - Repr. 2
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Olá! Qual a solubilidade da omadaciclina? Ela tem classificação BCS?
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