The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Immunogen
A synthetic phosphorylated peptide around S1083 of human BRD4 (NP_490597.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Zastosowanie
WB
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