SAB4702100

Monoclonal Anti-Myeloperoxidase PE produced in mouse

• Synonim(y): MPO
• Kod UNSPSC: 12352203

Właściwości

• białko sprzężone: phycoerythrin (R-PE) conjugate
• Poziom jakości: 100
• rodzaj przeciwciała: primary antibodies
• klon: MPO421-8B2, monoclonal
• Postać: buffered aqueous solution
• reaktywność gatunkowa: human
• metody: flow cytometry: suitable
• izotyp: IgG1
• numer dostępu UniProt: P05164
• temp. przechowywania: 2-8°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... MPO(4353)

Opis

Opis ogólny

Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.

Specyficzność

The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in intracellular granules of myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.

Immunogen

Human myeloperoxidase

Postać fizyczna

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Uwaga dotycząca przygotowania

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Przechowywanie i stabilność

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Inne uwagi

The antibody solution should be gently mixed before use.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable