SAB4501536

Anti-IKK-β antibody produced in rabbit

affinity isolated antibody

• Synonim(y): I-κ-B kinase 2, I-κ-B-kinase β, IKK-β, IKK-B, IKK2
• Numer MDL: MFCD02263521
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Formularz: buffered aqueous solution
• masa cząsteczkowa: antigen 86 kDa
• reaktywność gatunkowa: mouse, rat, human
• stężenie: ~1 mg/mL
• metody: ELISA: 1:10000; immunohistochemistry: 1:50-1:100
• numer dostępu NCBI: O14920
• numer dostępu UniProt: O14920
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... IKBKB(3551)

Opis

Opis ogólny

IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.

Immunogen

The antiserum was produced against synthesized peptide derived from human IKK-beta.

Immunogen Range: 166-215

Zastosowanie

Anti-IKK-β antibody produced in rabbit has been used in western blotting.

Działania biochem./fizjol.

Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).

Cechy i korzyści

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Postać fizyczna

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable