SAB4300635

Anti-EWS antibody produced in rabbit

affinity isolated antibody

• Synonim(y): Anti-EWSR1, Anti-bK984G1.4
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: ~85 kDa
• reaktywność gatunkowa: mouse, rat, human
• stężenie: 1 mg/mL
• metody: western blot: 1:500-1:1000
• izotyp: IgG
• sekwencja immunogenna: (T-Y-G-Q-P)
• numer dostępu NCBI: NM_013986.3
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... EWS(2130)

Opis

Opis ogólny

The antibody detects endogenous levels of total EWS protein.

Immunogen

Peptide sequence around aa. 213-217 (T-Y-G-Q-P), according to the protein NP_053733.2

Cechy i korzyści

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Opis wartości docelowych

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable