S7071

SD-208

Name: SD-208
Brand: SIGMA
Price: 786.25 PLN

≥98% (HPLC), powder

Synonim(y):

2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

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5 MG

786,25 zł

25 MG

2694,50 zł

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Wzór empiryczny (zapis Hilla):

C₁₇H₁₀ClFN₆

Numer CAS:

627536-09-8

Masa cząsteczkowa:

352.75

NACRES:

NA.77

PubChem Substance ID:

24899731

UNSPSC Code:

12352200

MDL number:

MFCD11519969

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white to tan

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2

InChI

1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)

InChI key

BERLXWPRSBJFHO-UHFFFAOYSA-N

Powiązane kategorie

Bioactive Small Molecule Inhibitors

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Ta pozycja	SML2819	SML1565	SML0661
Sigma-Aldrich S7071 SD-208	Sigma-Aldrich SML2819 AZ12799734	Sigma-Aldrich SML1565 A-196	Sigma-Aldrich SML0661 ML216
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >5 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear (warmed)
color off-white to tan	color white to beige	color white to light brown	color light orange to dark orange

Application

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

Biochem/physiol Actions

SD-208 is TGF-βR I kinase inhibitor with IC₅₀ =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

SD-208 is a novel transforming growth factor beta receptor I (TGF-βR I) kinase inhibitor. SD-208 inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Odwiedź Bibliotekę dokumentów

Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

Rob J Van Geest et al.

Investigative ophthalmology & visual science, 51(4), 1857-1865 (2009-12-05)

Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a multipotent cytokine acting through its receptors ALK5 and -1, has been postulated to be involved in this phenomenon. In light of this

Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.

Audrey Lamora et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 20(19), 5097-5112 (2014-08-12)

Osteosarcoma is the main malignant primary bone tumor in children and adolescents for whom the prognosis remains poor, especially when metastasis is present at diagnosis. Because transforming growth factor-β (TGFβ) has been shown to promote metastasis in many solid tumors

Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.

Elisa Ventura et al.

Journal of immunology (Baltimore, Md. : 1950), 198(12), 4569-4574 (2017-05-10)

Glioblastoma is the most common and aggressive intrinsic brain tumor in adults. Self-renewing, highly tumorigenic glioma-initiating cells (GIC) have been linked to glioma invasive properties, immunomodulation, and increased angiogenesis, leading to resistance to therapy. TGF-β signaling has been associated with

Myofibroblast modulation of cardiac myocyte structure and function.

Chandan K Nagaraju et al.

Scientific reports, 9(1), 8879-8879 (2019-06-22)

After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and the interstitial fibrosis seen in the adjacent myocardium. Fb and MyoFb have the potential to interact with cardiac myocytes (CMs) but insight into the phenotype-specific

Tanja Stüber et al.

Journal for immunotherapy of cancer, 8(1) (2020-04-19)

Immunotherapy with chimeric antigen receptor (CAR)-engineered T-cells is effective in some hematologic tumors. In solid tumors, however, sustained antitumor responses after CAR T-cell therapy remain to be demonstrated both in the pre-clinical and clinical setting. A perceived barrier to the

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
S7071-25MG	04061832449739
S7071-5MG	04061832449746

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