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Merck

S6448

SYK, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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10 μG

2100,00 zł

2100,00 zł

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Informacje o tej pozycji

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
79-107 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

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Pozwól nam pomóc

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

79-107 nmol/min·mg

mol wt

~100 kDa

UniProt accession no.

P43405

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

Quality Level

200

Gene Information

human ... SYK(6850)

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Ta pozycja
SRP0336M0699C1245
SYK, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

S6448

SYK, active, GST tagged human

SYK Catalytic Subunit active human recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

Sigma-Aldrich

SRP0336

SYK Catalytic Subunit active human

MSK1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M0699

MSK1, active, GST tagged human

CLK1 (129-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C1245

CLK1 (129-end), active, GST tagged human

specific activity

79-107 nmol/min·mg

specific activity

≥139 pmol/min-μg

specific activity

75-103 nmol/min·mg

specific activity

170-230 nmol/min·mg

assay

≥70% (SDS-PAGE)

assay

≥60% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... SYK(6850)

Gene Information

human ... SYK(6850)

Gene Information

human ... RPS6KA5(9252)

Gene Information

human ... CLK1(1195)

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Biochem/physiol Actions

SYK is a non-receptor protein tyrosine kinase that is widely expressed in hematopoietic cells. It is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. In B cells, SYK plays a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement.SYK has been shown to act as a potential tumor suppressor in breast cancer. Absence of SYK protein in primary breast tumors is correlated with poor outcomes. SYK deficient cells have increased motility that is restored to normalcy by replacement with wild-type SYK.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
SLBP2696V
SLBF2588V

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Tomoko Takano et al.
Antioxidants & redox signaling, 4(3), 533-541 (2002-09-07)
Oxidative stress induces the activation of multiple signaling pathways related to various cellular responses. In B cells, Syk has a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement. Treatment of B cells
Christopher S Navara
Current pharmaceutical design, 10(15), 1739-1744 (2004-06-08)
The spleen tyrosine kinase Syk is an enigmatic protein tyrosine kinase functional in a number of diverse cellular processes. It is best known as a non receptor protein tyrosine kinase involved in signal transduction in cells of hematopoietic origin and
Yu Yu et al.
Oncogene, 37(28), 3778-3789 (2018-04-13)
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active
Yu Yu et al.
EBioMedicine, 47, 184-194 (2019-09-08)
Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and directly

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