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S4026

Semustine

Name: Semustine
Brand: SIGMA

Synonim(y):

N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea, Methyl-CCNU

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₀H₁₈ClN₃O₂

Numer CAS:

13909-09-6

Masa cząsteczkowa:

247.72

NACRES:

NA.22

PubChem Substance ID:

24899584

UNSPSC Code:

12352100

MDL number:

MFCD00133811

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SMILES string

CC1CCC(CC1)NC(=O)N(CCCl)N=O

InChI

1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

InChI key

FVLVBPDQNARYJU-UHFFFAOYSA-N

Powiązane kategorie

Chemical Building Blocks

Organic Building Blocks

Application

Commonly used in pharmacological studies involving:

Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis
CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma
Investigations into its use for chemotherapy

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H311 + H331,H315,H319,H335,H350,H360

pcodes

P202 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certyfikaty analizy (CoA)

Lot/Batch Number

091H0080

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A comparative study of outcomes of idarubicin- and etoposide-intensified conditioning regimens for allogeneic peripheral blood stem cell transplantation in patients with high-risk acute leukemia.

Qiu-bai Li et al.

Acta pharmacologica Sinica, 30(10), 1471-1478 (2009-09-22)

To analyze the results of idarubicin (IDA)- versus etoposide (VP16)-intensified myeloablative conditioning regimen in allogeneic hematopoietic stem cell transplantation (allo-SCT) for high-risk acute leukemia. From January 2005 to June 2008, 48 consecutive patients (male: n=29; median age: 30 years, range

ANCA vasculitis: time for a change in treatment paradigm? Not yet.

Eleana Ntatsaki et al.

Rheumatology (Oxford, England), 50(6), 1019-1024 (2011-02-05)

The ANCA-associated vasculitides (AAVs) are conventionally treated with a strategy of remission induction followed by maintenance therapy using glucocorticoids combined with CYC during induction and AZA for maintenance. Recently, several randomized controlled trials have been published that question whether these

Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry.

Baoqing Bai et al.

Rapid communications in mass spectrometry : RCM, 25(14), 2027-2034 (2011-06-24)

Chloroethynitrosoureas (CENUs) are important alkylating agents widely used in the treatment of cancers. Decomposition of CENUs generates active electrophilic ions that damage DNA, including the formation of dG-dC crosslinks which represents the most important cytotoxic mechanism of CENUs. In this

[Advances in research on capecitabine as adjuvant treatment for colon cancer after radical resection].

Su-Zhan Zhang

Zhonghua zhong liu za zhi [Chinese journal of oncology], 32(11), 801-803 (2011-01-13)

A randomized phase II study of CEOP with or without semustine as induction chemotherapy in patients with stage IE/IIE extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract.

Xuejun Ma et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 93(3), 492-497 (2009-09-29)

In this randomized phase II study, we evaluated the efficacy of semustine added to CEOP regimen as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract. Seventy-five eligible patients were randomized to

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Powiązane treści

Semustine (S4026)

Numer pozycji handlu globalnego

SKU	NUMER GTIN
S4026-100MG	04061832857862

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