S1688

SR 57227A

solid

• Synonim(y): 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₀H₁₄ClN₃ · HCl
• Numer CAS: 77145-61-0
• Masa cząsteczkowa: 248.15
• NACRES: NA.77
• PubChem Substance ID: 24278109
• UNSPSC Code: 12352200
• MDL number: MFCD01756430
• Form: solid

Właściwości

• form: solid
• Quality Segment: 100
• color: white
• solubility: H₂O: soluble 9 mg/mL
• SMILES string: Cl.NC1CCN(CC1)c2cccc(Cl)n2
• InChI: 1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
• InChI key: FUMINTAAUJUVMP-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Opis

Application

SR 57227A may be used in 5-HT₃-mediated cell signaling studies.

Biochem/physiol Actions

Potent and selective 5-HT₃ serotonin receptor agonist.

SR 57227A is a highly selective of central and peripheral 5-HT₃ receptors[1] and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells.[2] It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.[3]

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Informacja o środkach bezpieczeństwa

• signalword: Danger
• pictograms: GHS06
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges