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P9246

PB28 dihydrochloride

Name: PB28 dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonim(y):

1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride

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Informacje o tej pozycji

Wzór liniowy:

C₂₄H₄₀Cl₂N₂O

Numer CAS:

172906-90-0

Masa cząsteczkowa:

443.49

NACRES:

NA.77

PubChem Substance ID:

329820345

UNSPSC Code:

12352200

MDL number:

MFCD06798349

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: ~10 mg/mL at 60 °C

SMILES string

Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12

InChI

1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H

InChI key

DSRBJOQIBXACIV-UHFFFAOYSA-N

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Ta pozycja	U3885	D052	L3169
Sigma-Aldrich P9246 PB28 dihydrochloride	Sigma-Aldrich U3885 UK-78282 monohydrochloride	Sigma-Aldrich D052 GBR 12909 dihydrochloride	Sigma-Aldrich L3169 LP 12 hydrochloride hydrate
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: ~10 mg/mL at 60 °C	solubility DMSO: >10 mg/mL	solubility DMSO: >5 mg/mL (Solutions freshly prepared daily)	solubility DMSO: >5 mg/mL, H₂O: 6 mg/mL
storage condition desiccated	storage condition desiccated	storage condition -	storage condition -
color white	color white to off-white	color white	color off-white

Application

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.[1]

Biochem/physiol Actions

PB28, a cyclohexylpiperazine derivative,[2] is a sigma 1 (σ1)-R antagonist.[1] It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.[3]

Selective σ₂opioid receptor ligand; putative σ₂ agonist

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number

064K4610

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Odwiedź Bibliotekę dokumentów

Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel.

Xinying Liu et al.

Oncotarget, 8(35), 59345-59358 (2017-09-25)

The sigma-1 receptor (σ1-R) and sigma-2 receptor (σ2-R) are potential drug targets for treatment of cancer, pain, depression, retinal degeneration and other neuronal diseases. Previous reports show that sigma-1 receptor modulates the activities of multiple channels. We are interested in

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder.

Nicola A Colabufo et al.

Naunyn-Schmiedeberg's archives of pharmacology, 368(2), 106-112 (2003-07-25)

We demonstrated the presence of sigma(2) receptors in the guinea-pig ileum by saturation analysis and extended our investigation to guinea-pig bladder and rat bladder. In functional assays of the isolated tissues in organ baths, sigma(2) receptor ligands inhibited electrically evoked

Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer.

Nicola Antonio Colabufo et al.

Cancer letters, 237(1), 83-88 (2005-07-12)

Sigma2 (sigma2) receptor proteins are overexpressed in several tissues and tumour cell lines. Although the biomolecular mechanism of this overexpression must be elucidated, sigma2 receptor was considered a potential biomarker for monitoring solid tumour proliferation. In this study, we verified

Study of the Relationship between Sigma Receptor Expression Levels and Some Common Sigma Ligand Activity in Cancer Using Human Cancer Cell Lines of the NCI-60 Cell Line Panel.

Evangelia Sereti et al.

Biomedicines, 9(1) (2021-01-21)

Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). Both σ receptor

Numer pozycji handlu globalnego

SKU	NUMER GTIN
P9246-5MG	04061832558011

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