Przejdź do zawartości
Merck

Kluczowe dokumenty

Wyświetl całą dokumentację

Przejdź do

P4394

cis-Diammineplatinum(II) dichloride

≥99.99% (trace metal analysis), crystalline, macrophage activator

Synonim(y):

cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.

Wybierz wielkość

Zmień widok
Do Państwa/SKUDostępnośćCena netto
25 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
303,00 zł
100 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
408,00 zł
250 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
739,00 zł
1 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
2180,00 zł

Informacje o tej pozycji

Wzór liniowy:
Pt(NH3)2Cl2
Numer CAS:
15663-27-1
Masa cząsteczkowa:
300.05
NACRES:
NA.77
PubChem Substance ID:
24278632
UNSPSC Code:
12352200
EC Number:
239-733-8
MDL number:
MFCD00011623
Form:
crystalline

303,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
​
Złóż zamówienie na produkt na zamówienie
Pomoc techniczna
Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.
Pozwól nam pomóc

Nazwa produktu

cis-Diammineplatinum(II) dichloride, crystalline

form

crystalline

Quality Segment

200

color

yellow

mp

270 °C (lit.)

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

originator

Corden

SMILES string

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

Application

cis-Diammineplatinum(II) dichloride has been used:
  • in cell viability measurement in cochlear explants[1]
  • in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
  • in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Biochem/physiol Actions

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Porównaj podobne pozycje

Wyświetl pełne porównanie

Pokaż różnice

1 of 1

Ta pozycja
4793061134357BP809
cis-Diammineplatinum(II) dichloride crystalline

Sigma-Aldrich

P4394

cis-Diammineplatinum(II) dichloride

cis-Diamineplatinum(II) dichloride ≥99.9% trace metals basis

Sigma-Aldrich

479306

cis-Diamineplatinum(II) dichloride

Cisplatyna United States Pharmacopeia (USP) Reference Standard

USP

1134357

Cisplatyna

Cisplatin British Pharmacopoeia (BP) Reference Standard

BP809

Cisplatin

form

crystalline

form

-

form

-

form

solid

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

-

originator

Corden

originator

-

originator

-

originator

-

color

yellow

color

-

color

-

color

-

mode of action

DNA synthesis | interferes

mode of action

DNA synthesis | interferes

mode of action

-

mode of action

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

-

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

target_organs

Respiratory system

Klasa składowania

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.

Proszę o kontakt, jeśli potrzebna jest pomoc Obsługa Klienta

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Questions

1–9 of 9 Questions  

  1. How to reconstitute Cisplatin (P4394)?

    1 answer

    1. The list of solvents and rates are as follows:
      Solvent M x 10E(2) %(w/v)
      H2O(after 24 hours)* 0.77 0.23
      (after 72 hours)* 0.83 0.25
      0.9% NaCl 0.50 0.15
      DMF 6.67 2.0
      DMA 6.00 1.8
      DMSO* 116.6 35.0
      *strongly discouraged
      DMSO inserts itself into the ligand

      Please see the link below to review this product datasheet for additional information:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/310/148/p4394pis.pdf

      Helpful?

  2. How long can it be stored at -20°C when it is dissolved in PBS?

    1 answer

    1. The long term stability of this material in solution has not been determined. In general, it is recommended to prepare solutions fresh and protect from light. However, at -20°C, Cisplatin is completely stable over a span of 2 weeks according to the article below:
      https://onlinelibrary.wiley.com/doi/full/10.1002/%28SICI%291097-0142%2819970501%2979%3A9%3C1723%3A%3AAID-CNCR13%3E3.0.CO%3B2-%23

      Helpful?

  3. How should the Product cisplatin P4394, be stored?

    1 answer

    1. This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/310/148/p4394pis.pdf

      Helpful?

  4. Why should DMSO not be used as a solvent for cis-Diammineplatinum (II) dichloride?

    1 answer

    1. The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride.  The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity.  Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.

      Helpful?

  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  6. What is the best solvent to use for Cisplatin, Product P4394?

    1 answer

    1. Pharmaceutical injections of cisplatin are in 0.9% sodium chloride at 1 mg/ml.  A 0.1% solution in 0.9% sodium chloride solution has a pH range of 4.5-6.0 immediately after preparation and can be adjusted with HCl.

      Helpful?

  7. What is the half-life of Cisplatin, Product P4394, in DMSO?

    1 answer

    1. At 37 °C, the half-life of cisplatin in DMSO is 60 minutes. In vivo the half-life of cisplatin is approximately 30 minutes.

      Helpful?

  8. What is the toxicity of Cisplatin, Product P4394?

    1 answer

    1. This information can be found on the MSDS Section 11.

      Helpful?

  9. How can solutions of Cisplatin, Product P4394, be stored?

    1 answer

    1. Sterile solutions in 0.9% sodium chloride protected from light are stable for 28 days at room temperature.

      Helpful?

Reviews

No rating value

Active Filters