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Merck

BP809

Cisplatin

British Pharmacopoeia (BP) Reference Standard

Synonim(y):

cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

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Informacje o tej pozycji

Wzór liniowy:
Pt(NH3)2Cl2
Numer CAS:
15663-27-1
Masa cząsteczkowa:
300.05
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
239-733-8
MDL number:
MFCD00011623

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grade

pharmaceutical primary standard

API family

cisplatin

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

270 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cisplatin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Cisplatin Injection

    • Biochem/physiol Actions

    Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.
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    pictograms

    Skull and crossbonesHealth hazard
    GHS06,GHS08

    signalword

    Danger

    target_organs

    Respiratory system

    Klasa składowania

    6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    Hazard Classifications

    Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

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    Lot/Batch Number

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    Odwiedź Bibliotekę dokumentów

    Shihong Ma et al.
    Journal of cellular biochemistry, 121(5-6), 3256-3265 (2020-01-07)
    Aberrant activation of the Hedgehog (Hh)/Gli pathway contributes to the tumorigenesis of several human cancers, including ovarian cancers. We investigated the function of SMO on cell growth, drug resistance, and invasive ability in A2780/DDP cells. Moreover, we also tested the
    Xiaochen Wang et al.
    Stem cells international, 2020, 8877577-8877577 (2020-09-05)
    Esophageal squamous cell carcinoma (ESCC) is a frequent malignant tumor with low 5-year overall survival. Targeting ESCC tumor-initiating cells (TICs) may provide a new research avenue to achieve better therapeutic effects of ESCC. However, the identity and characteristics of ESCC
    Ruiqian Li et al.
    International urology and nephrology, 52(1), 187-196 (2019-12-13)
    Cisplatin could result in a wide range of kidney injuries. During the pathogenetic process, the excessive generation of reactive oxygen species (ROS) induced by cisplatin has been regarded as the initial and critical role, by which DNA damage and cell
    Teng Wang et al.
    Biochimica et biophysica acta. Molecular cell research, 1867(12), 118833-118833 (2020-08-30)
    Epithelial-mesenchymal transition (EMT) is considered as the key mechanism involved in cancer metastasis. Several studies showed that various cell membrane calcium channels play different roles in cancer metastasis. In the present study, the potential role of ATPase plasma membrane Ca2+
    Tengfei Liu et al.
    Nature communications, 11(1), 2788-2788 (2020-06-05)
    Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the
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    Numer pozycji handlu globalnego

    SKUNUMER GTIN
    BP80904061835275700

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