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P354-05
Porcine Aortic Smooth Muscle Cells: PAOSMC (Cryovial)
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|
Informacje o tej pozycji
biological source
Porcine aorta (normal)
Quality Level
form
solid
packaging
pkg of 500,000 cells
manufacturer/tradename
Cell Applications, Inc
growth mode
Adherent
karyotype
2n = 38
morphology
smooth muscle
technique(s)
cell culture | mammalian: suitable
relevant disease(s)
cardiovascular diseases
1 of 1
Ta pozycja | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| biological source Porcine aorta (normal) | biological source Porcine pulmonary artery | biological source Porcine pulmonary artery (Normal healthy) | biological source bovine pulmonary artery (tunica intima and media) |
| growth mode Adherent | growth mode Adherent | growth mode Adherent | growth mode Adherent |
| relevant disease(s) cardiovascular diseases | relevant disease(s) cardiovascular diseases | relevant disease(s) diabetes; cardiovascular diseases | relevant disease(s) cardiovascular diseases |
| morphology smooth muscle | morphology smooth muscle | morphology Endothelial | morphology smooth muscle |
| karyotype 2n = 38 | karyotype 2n = 38 | karyotype 2n = 38 | karyotype 2n = 60 |
General description
PAOSMC were used to investigate the effects of heparin on smooth muscle cell proliferation, specifically revealing that heparin induces MKP-1 phosphatase that dephosphorylates ERK, decreasing its activity (Blaukovitch, 2010). They were also used to show that normalization of myocardin signaling in the diseased heart by using targeted inhibition of myocardin genes by shRNA restores heart function (Torrado, 2011). Finally, PAOSMC along with Porcine Aortic Endothelial cells, have been used as controls in a study characterizing circulating endothelial progenitor cells (Allen, 2008).
Characterization: positive for smooth muscle cell specific alpha-actin expression.
Application
Biochem/physiol Actions
Preparation Note
- 1st passage, >500,000 cells in Porcine Smooth Muscle Cell Basal Medium that contains 10% FBS and 10% DMSO
- Can be cultured at least 16 doublings
Other Notes
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| P354-05 | 04061834368168 |
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