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P105

Sigma-Aldrich

(±)-PPHT hydrochloride

≥98% (HPLC), solid

Synonim(y):

(±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

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About This Item

Wzór empiryczny (zapis Hilla):
C21H27NO · HCl
Numer CAS:
71787-90-1
Masa cząsteczkowa:
345.91
Numer MDL:
MFCD00055157
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24277925

Próba

≥98% (HPLC)

Postać

solid

kolor

off-white

rozpuszczalność

DMSO: ≥10 mg/mL
H2O: ≥2 mg/mL

ciąg SMILES

Cl[H].CCCN(CCc1ccccc1)C2CCc3c(O)cccc3C2

InChI

1S/C21H27NO.ClH/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23;/h3-10,19,23H,2,11-16H2,1H3;1H

Klucz InChI

XWLCIDLCEZAOEY-UHFFFAOYSA-N

informacje o genach

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Działania biochem./fizjol.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.
Potent D2 dopamine receptor agonist.
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Kod klasy składowania

13 - Non Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

B Kanyicska et al.
Endocrinology, 138(8), 3141-3153 (1997-08-01)
Endothelin-1 (ET-1) inhibits PRL secretion from cultured rat lactotrophs. However, ET-1 stimulates PRL secretion after cultured lactotrophs have been exposed for 48 h to dopamine or D2 dopamine agonists. In the present study, we have used cell-attached and inside-out patch
M E Meyer et al.
Pharmacology, biochemistry, and behavior, 44(4), 865-868 (1993-04-01)
The effects of a dopamine agonist, (+/-)-2-(N-penylethyl-N-propyl)amino-5- hydroxytetralin (N-0434) (SC doses of 0.00, 0.01, 0.1, and 1.0 mg/kg) were tested in rats for 120 min in an activity monitor. The durations in seconds of horizontal locomotor time, rearing time, stereotypy
G Díaz-Véliz et al.
Pharmacology, biochemistry, and behavior, 62(1), 21-29 (1999-02-11)
The influence of the hormonal condition on the reactivity of central dopamine (DA) receptors was studied in male and in intact and ovariectomized (OVX) female rats. They were injected with selective DA agonists, acting either on D1 (SKF 38393, 2.5
A C Barton et al.
Brain research, 547(2), 199-207 (1991-05-13)
We report the synthesis and pharmacological characterization of novel fluorescently labeled ligands with high affinity and specificity for D1 and D2 dopamine receptors. D1-selective antagonist probes have been synthesized using (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3-methyl-[1H]-3- benzazepin-7-ol, the 4'-amino derivative of the high affinity D1-selective
F J Bosker et al.
European journal of pharmacology, 163(2-3), 319-326 (1989-04-25)
Partial purification of the dopamine D-2 receptor from bovine striatum, solubilized in the presence of 1% digitonin, was obtained by chromatography on wheat germ lectin agarose. The preparation was purified approximately 10-fold. The stability of the receptor preparation was considerably
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