P105
(±)-PPHT hydrochloride
≥98% (HPLC), solid
Synonim(y):
(±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C21H27NO · HCl
Numer CAS:
Masa cząsteczkowa:
345.91
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Pomoc techniczna
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Pozwól nam pomócPomoc techniczna
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Pozwól nam pomócassay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: ≥10 mg/mL, H2O: ≥2 mg/mL
SMILES string
Cl[H].CCCN(CCc1ccccc1)C2CCc3c(O)cccc3C2
InChI
1S/C21H27NO.ClH/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23;/h3-10,19,23H,2,11-16H2,1H3;1H
InChI key
XWLCIDLCEZAOEY-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Biochem/physiol Actions
(±)-PPHT hydrochoride is a potent D2 dopamine receptor agonist
A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.
Potent D2 dopamine receptor agonist.
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Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
P Seeman et al.
Molecular pharmacology, 28(5), 391-399 (1985-11-01)
In order to develop a model for the putative binding sites between the D2 dopamine receptor and many of its agonists, we obtained the dissociation constants of many dopaminergic agonists at the high affinity state, D2high, as well as at
A Mao et al.
Life sciences, 59(21), PL317-PL324 (1996-01-01)
The concentrations of endogenous ligands generally remain in a bounded range around a basal level, a manifestation of control. The dopaminergic system is an excellent example of a control system in which a negative feedback signal is associated with receptor
F J Bosker et al.
European journal of pharmacology, 163(2-3), 319-326 (1989-04-25)
Partial purification of the dopamine D-2 receptor from bovine striatum, solubilized in the presence of 1% digitonin, was obtained by chromatography on wheat germ lectin agarose. The preparation was purified approximately 10-fold. The stability of the receptor preparation was considerably
M P Seiler et al.
Journal of medicinal chemistry, 29(6), 912-917 (1986-06-01)
5-Hydroxy-2-aminotetralin derivatives in which one N-alkyl substituent carries a functional group have been prepared and their dopaminergic activities compared with those of 5-hydroxy-2-(di-n-propylamino)tetralin (5-OH-DPAT) and known ergolines. Several members of the series demonstrated high affinities in dopamine (DA) receptor binding
M A Ariano et al.
Brain research, 547(2), 208-222 (1991-05-03)
Selective dopamine receptor ligands, (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4, 5-tetrahydro-3-methyl-[1H]-3-benzazepin-7-ol, the 4'-amino derivative of the high affinity D1 receptor antagonist SCH 23390, the high affinity D2 receptor antagonist N-(p-aminophenethyl)-spiperone or NAPS, and the D2 selective agonist, 2-(N-phenethyl-N-propyl)-amino-5-hydroxytetralin or PPHT were chemically coupled to the
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 86216-5G | 04061833359099 |
| SAB4501991-100UG | 04061835714285 |
| SAB4501989-100UG | 04061837189081 |
| SAB4501990-100UG | 04061835714278 |
| SAB1305889-400UL | 04061835628926 |
| SAB5600110-100UL | 04061833351253 |
| SAB4504486-100UG | 04061831456608 |
| SAB4504487-100UG | 04061832526164 |
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