P1038

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

• Synonim(y): Poly (C,I)
• Numer CAS: 26301-44-0
• UNSPSC Code: 41106305
• NACRES: NA.51
• MDL number: MFCD00167396
• Form: powder
• Storage temp.: −20°C

Właściwości

• Quality Segment: 200
• form: powder
• storage temp.: −20°C

Opis

Application

Poly(cytidylic-inosinic) acid potassium salt has been used:

• in pretreatment to understand Con A-induced hepatitis in mice
• in RNA extraction from hemolymph plasma for qPCR detection assay
• to induce inflammatory changes in liver
• as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells

Biochem/physiol Actions

Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.

Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).

Other Notes

Random copolymer

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)