N2162

NH125

≥98% (HPLC), solid

• Synonim(y): 1-Benzyl-3-cetyl-2-methylimidazolium iodide
• Wzór empiryczny (zapis Hilla): C₂₇H₄₅IN₂
• Numer CAS: 278603-08-0
• Masa cząsteczkowa: 524.56
• NACRES: NA.77
• PubChem Substance ID: 329818598
• UNSPSC Code: 12352200
• MDL number: MFCD07370143
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• mp: 88.2-94.9 °C
• solubility: DMSO: >20 mg/mL
• storage temp.: −20°C
• SMILES string: [I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C
• InChI: 1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
• InChI key: RVWOHCBHAGBLLT-UHFFFAOYSA-M

Opis

Biochem/physiol Actions

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

Packaging

Packaged under nitrogen.

Analysis Note

IC₅₀ = 60 nM for eEF-2 kinase vs protein kinase C (IC₅₀= 7.5 μM), protein kinase A (IC₅₀= 80 μM), and calmodulin-dependent kinase II IC₅₀ > 100 μM).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves