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Merck

MAK034

Coenzyme A (CoA) Assay Kit

sufficient for 100 colorimetric or fluorometric tests

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Informacje o tej pozycji

NACRES:
NA.84
UNSPSC Code:
12161503

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Nazwa produktu

Coenzyme A (CoA) Assay Kit, sufficient for 100 colorimetric or fluorometric tests

usage

sufficient for 100 colorimetric or fluorometric tests

detection method

colorimetric
fluorometric

functional group

phospholipid

relevant disease(s)

endocrinological disorders, diabetes; cancer

shipped in

wet ice

storage temp.

−20°C

Application

Coenzyme A (CoA) Assay Kit has been used to measure CoA levels.[1]
Suitable for the measurement of Coenzyme A (CoA) in a variety of biological samples including cell and tissue lysates

Biochem/physiol Actions

The Coenzyme A Assay kit is an easy and convenient assay to measure the CoA level in a variety of biological samples. CoA concentration is determined by an enzymatic assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535 nm/λem = 587 nm) product, proportional to the CoA present. Typical sensitivities of detection for this kit are 0.1-10 nmol of CoA.

Features and Benefits

Compatible with high-throughput handling systems.

General description

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP (adenosine triphosphate).[2] CoA plays important roles in many metabolic pathways, including the Tricarboxylic Acid cycle, and the synthesis and oxidation of fatty acids.[3] One of the main functions of CoA is the carrying and transfer of acyl groups.[4] Acylated deriviates, for example Acetyl-CoA, are critical intermediates in many metabolic reactions, particularly fatty acid and carbohydrate metabolism.[5] CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.[6][7][8]
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Numer produktu
Opis
Cennik

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H319,H334

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1

Klasa składowania

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
8J01K03670
6C23K03670
7F02K03670
6M15K03670
5K16K03670

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Molecular enzymology of carnitine transfer and transport.
Ramsay R R, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1546(1), 21-43 (2001)
Nonalcoholic fatty liver disease and mitochondrial dysfunction.
Wei Y, et al.
World Journal of Gastroenterology, 14(2), 193-193 (2008)
Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Rosen B C, et al.
Antimicrobial Agents and Chemotherapy, AAC-02130 (2016)
Brandon C Rosen et al.
Antimicrobial agents and chemotherapy, 61(2) (2016-11-18)
Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action. Based upon the observation that the minimum concentration of PZA required to inhibit the growth
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Science, 291(5513), 2613-2616 (2001)
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