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Merck

M7273

Sigma-Aldrich

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit

whole antiserum

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About This Item

Numer MDL:
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

whole antiserum

rodzaj przeciwciała

primary antibodies

klon

polyclonal

zawiera

15 mM sodium azide

reaktywność gatunkowa

mammals

metody

western blot: 1:200

numer dostępu UniProt

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

Opis ogólny

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).

Specyficzność

Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin.

Immunogen

heat stable MAPs prepared from bovine brain.

Zastosowanie

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:
  • immunofluorescent labelling
  • immunohistochemistry
  • immunoprecipitation
  • immunofluorescence staining
  • western blotting

Działania biochem./fizjol.

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Increased Phosphorylation of Ca/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation
Fukunaga K, et al.
Test, 270(11), 6119-6124 (1995)
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons
Coughlan CM, et al.
Neuroscience, 97(3), 591-600 (2000)
K L Loveland et al.
Biology of reproduction, 54(4), 896-904 (1996-04-01)
The testis is one of the most abundant sources of microtubule networks. These networks include mitotic and meiotic spindles, the spermatid manchette and axoneme, and the Sertoli cell cytoskeleton. Microtubules are composed of alpha- and beta-tubulin subunits that are polymerized
N Noshita et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 21(5), 557-567 (2001-05-03)
Release of cytochrome c from mitochondria to cytosol is a critical step in the mitochondrial-dependent signaling pathways of apoptosis. The authors have reported that manganese superoxide dismutase (Mn-SOD) attenuated cytochrome c release and apoptotic cell death after focal cerebral ischemia
Suzana Angelica Silva Lustosa et al.
TheScientificWorldJournal, 2014, 102541-102541 (2014-04-17)
Colorectal cancer dissemination depends on extracellular matrix genes related to remodeling and degradation of the matrix structure. This investigation intended to evaluate the association between FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 gene and protein expression levels in tumor tissue with

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