M6053

Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonim(y): Anti-MMP-3
• Numer MDL: MFCD03455413
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous glycerol solution
• masa cząsteczkowa: antigen 59 kDa; antigen (pro-form) 57 kDa
• reaktywność gatunkowa: human
• stężenie: ~1 mg/mL
• metody: western blot: 1:1000
• numer dostępu UniProt: P08254
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... MMP3(4314)

Opis

Opis ogólny

Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.

Specyficzność

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).

Działania biochem./fizjol.

Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids