M1275

Naproxen sodium

synthetic (organic), 98.0-102.0%, Prostaglandin H synthase 1 and 2 inhibitor, powder

• Synonim(y): (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
• Wzór empiryczny (zapis Hilla): C₁₄H₁₃NaO₃
• Numer CAS: 26159-34-2
• Masa cząsteczkowa: 252.24
• NACRES: NA.77
• PubChem Substance ID: 57654352
• UNSPSC Code: 12352200
• EC Number: 247-486-2
• MDL number: MFCD00058507
• Assay: 98.0-102.0%
• Form: powder

Właściwości

• Nazwa produktu: Naproxen sodium, 98.0-102.0%
• biological source: synthetic (organic)
• assay: 98.0-102.0%
• form: powder
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• originator: Bayer
• SMILES string: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
• InChI key: CDBRNDSHEYLDJV-FVGYRXGTSA-M
• Gene Information: human ... PTGS1(5742), PTGS2(5743)

Opis

General description

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.[1]

Biochem/physiol Actions

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves