I7003
Ibogaine hydrochloride
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Wzór empiryczny (zapis Hilla):
C20H26N2O · HCl
Numer CAS:
Masa cząsteczkowa:
346.89
UNSPSC Code:
12352200
EC Number:
227-687-1
MDL number:
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Pozwól nam pomócdrug control
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: soluble, methanol: soluble
application(s)
forensics and toxicology
SMILES string
Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2
Biochem/physiol Actions
CNS stimulant and hallucinogen; anti-convulsant.
Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ2 agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.
Preparation Note
Alkaloid isolated from the African shrub, Tabernanthe iboga.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
K K Szumlinski et al.
Pharmacology, biochemistry, and behavior, 63(3), 457-464 (1999-07-27)
Pretreatment (19 h) with the putative antiaddictive agent, ibogaine, has been shown previously to potentiate cocaine-induced locomotion in rats. The present study demonstrates that the magnitude of this effect of ibogaine is dependent on the previous cocaine history of the
G B Wells et al.
Brain research bulletin, 48(6), 641-647 (1999-07-01)
Ibogaine has been shown to affect biogenic amine levels in selected brain regions. Because of the involvement of these neurotransmitters in drug addiction, the effects of ibogaine on biogenic amine transport may contribute to the potential anti-addictive properties of ibogaine
M B Leal et al.
Neurochemical research, 25(8), 1083-1087 (2000-10-31)
Ibogaine, a putative antiaddictive drug, is remarkable in its apparent ability to downgrade withdrawal symptoms and drug craving for extended periods of time after a single dose. Ibogaine acts as a non-competitive NMDA receptor antagonist, while NMDA has been implicated
Y Itzhak et al.
Annals of the New York Academy of Sciences, 844, 245-251 (1998-07-21)
Although the alkaloid ibogaine is a potent hallucinogenic agent some indications suggest that it may be useful for the treatment of opioid and cocaine addiction. The neurochemical mechanism(s) underlying ibogaine effects remain unclear. In the present study we investigated the
M K Mundey et al.
British journal of pharmacology, 129(8), 1561-1568 (2000-04-26)
Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at mu-opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spontaneous contractions of
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