I1661

ICA-105574

≥98% (HPLC)

• Synonim(y): 3-nitro-N-(4-phenoxyphenyl)-benzamide
• Wzór empiryczny (zapis Hilla): C₁₉H₁₄N₂O₄
• Numer CAS: 316146-57-3
• Masa cząsteczkowa: 334.33
• Numer MDL: MFCD01596399
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329815355

Właściwości

• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: off-white to light tan
• rozpuszczalność: DMSO: >20 mg/mL
• temp. przechowywania: room temp
• ciąg SMILES: [O-][N+](=O)c1cccc(c1)C(=O)Nc2ccc(Oc3ccccc3)cc2
• InChI: 1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
• Klucz InChI: GDWKBKTVROCPNZ-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

hERG (Kv11.1) is a voltage-gated potassium channel with important cardiovascular function. Many potential and marketed drugs bind to and inhibit hERG function, causing prolongation of the electrocardiogram QT interval, which leads to life-threatening ventricular arrhythmias. Understanding of hERG function is critical for drug discovery and development. hERG exhibits a unique bell-shaped current-voltage relationship which is a result of very rapid inactivation of the channel upon voltage activation. ICA-105574 is a small molecule activator of hERG that binds to the channel to remove inactivation, thereby increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. ICA-105574 differs in efficacy, mechanism of action, and/or binding site from other known hERG activators and enhancers. This compound is a valuable tool for furthering understanding of hERG biophysics and physiology, expecially the structural transitions that occur during inactivation.

Cechy i korzyści

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H317,H319,H400
• Zwroty wskazujące środki ostrożności: P273 - P280 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1
• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable