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Dokumenty

HPA004810

Sigma-Aldrich

Anti-IFITM1 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonim(y):

Anti-CD225 antigen, Anti-Interferon-induced protein 17, Anti-Interferon-induced transmembrane protein 1, Anti-Interferon-inducible protein 9-27, Anti-Leu-13 antigen

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About This Item

Kod UNSPSC:
12352203
Numer w atlasie ludzkich białek:
HPA004810
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

linia produktu

Prestige Antibodies® Powered by Atlas Antibodies

Postać

buffered aqueous glycerol solution

reaktywność gatunkowa

human

rozszerzona walidacja

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

metody

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

sekwencja immunogenna

MHKEEHEVAVLGAPPSTILPRSTVINIHSETSVPDH

numer dostępu UniProt

P13164

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... IFITM1(8519)

Opis ogólny

IFITM1 (interferon induced transmembrane protein 1) is a member of interferon inducible transmembrane protein (IFITM) family. It is expressed in stable blood vessels of multiple organs.

Immunogen

Interferon-induced transmembrane protein 1 recombinant protein epitope signature tag (PrEST)

Zastosowanie

Anti-IFITM1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Działania biochem./fizjol.

IFITM1 (interferon induced transmembrane protein 1) is associated with several cellular processes, such as homotypic cell adhesion of interfereons and cellular anti-proliferative activities. It essentially plays a role in the formation of functional blood vessels. IFITM1 regulates tight junction assembly that stabilizes EC-EC (endothelial cells) interactions during endothelial lumen formation. It acts as a biomarker in endometrial stromal and smooth muscle tumors. It performs in the antiproliferative action of IFN-γ. The suppressed expression of IFITM1 inhibits antiproliferative property of IFN-γ as well as enhances the cell growth. Studies have been suggested that IFITM1 inhibits the extracellular signaling of the kinase. By binding, it increases the transcriptional activity of p53 and stabilizes the p53 protein through inhibition of p53 phosphorylation on threonine residue.

Cechy i korzyści

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Powiązanie

Corresponding Antigen APREST86661

Postać fizyczna

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Informacje prawne

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Mirella Mourad et al.
Scientific reports, 11(1), 14390-14390 (2021-07-15)
The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women
Hui Sun et al.
Reproductive sciences (Thousand Oaks, Calif.), 27(8), 1595-1601 (2020-05-22)
When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is also expressed
Stephanie A Popson et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(5), 1011-1019 (2014-03-08)
It is well established that angiogenesis is a complex and coordinated multistep process. However, there remains a lack of information about the genes that regulate individual stages of vessel formation. Here, we aimed to define the role of human interferon-induced
Ji-Su Mo et al.
Immunology letters, 156(1-2), 118-122 (2013-10-15)
Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility
Carlos E Parra-Herran et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(4), 569-579 (2013-09-28)
When classifying cellular uterine mesenchymal neoplasms, histological distinction of endometrial stromal from smooth muscle neoplasms can be difficult. The only widely established marker of endometrial stromal differentiation, CD10, has marginal specificity. We took a bioinformatics approach to identify more specific
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