H9911
Anti-Hepatocyte Growth Factor Receptor antibody produced in goat
lyophilized powder, affinity isolated antibody
Synonim(y):
Anti-HGF Receptor
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About This Item
Polecane produkty
pochodzenie biologiczne
goat
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
lyophilized powder
reaktywność gatunkowa
mouse
metody
immunohistochemistry: 5-15 μg/mL using using cells and tissue
western blot: 0.1-0.2 μg/mL
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
mouse ... Met(17295)
Powiązane kategorie
Opis ogólny
Blockade of receptor-ligand interaction: In a functional ELISA, 0.3-1 μg/mL of this antibody will block 50% of the binding of 5 ng/mL of Recombinant Human HGF to immobilized Recombinant Mouse HGF R/cMET Fc Chimera coated at 1 μg/mL (100 μL/well). At 20 μg/mL, this antibody will block >90% of the binding.
Immunogen
purified recombinant mouse hepatocyte growth factor receptor extracellular domain expressed in insect Sf 21 cells.
Działania biochem./fizjol.
Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility, adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (pH 7.4) with 5% trehalose.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
H Ohmichi et al.
The American journal of physiology, 270(6 Pt 1), L1031-L1039 (1996-06-01)
Hepatocyte growth factor (HGF) has mitogenic, morphogenic, and motogenic activities on epithelial cells and plays important roles in regeneration of the liver and the kidney. We previously found that the expression of HGF gene is rapidly induced in the lung
Toshikazu Nakamura et al.
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 86(6), 588-610 (2010-06-17)
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor
K Matsumoto et al.
Critical reviews in oncogenesis, 3(1-2), 27-54 (1992-01-01)
Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF was first purified from rat platelets in 1986. HGF
Shinya Mizuno et al.
Frontiers in bioscience : a journal and virtual library, 13, 7072-7086 (2008-05-30)
Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target
Weon-Kyoo You et al.
BMB reports, 41(12), 833-839 (2009-01-07)
Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this
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