H7768

12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

~100 μg/mL in ethanol, ≥95% (HPLC)

• Synonim(y): (S)-12-HETE
• Wzór empiryczny (zapis Hilla): C₂₀H₃₂O₃
• Numer CAS: 54397-83-0
• Masa cząsteczkowa: 320.47
• UNSPSC Code: 12352106
• NACRES: NA.77
• PubChem Substance ID: 24895806
• EC Number: 200-578-6
• Beilstein/REAXYS Number: 2656104
• MDL number: MFCD00036916

Właściwości

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: liquid
• concentration: ~100 μg/mL in ethanol
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
• InChI key: ZNHVWPKMFKADKW-LQWMCKPYSA-N

Opis

Biochem/physiol Actions

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca²⁺-activated K⁺ currents in coronary microvascular smooth muscle.

Packaging

Packaged under Argon.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Klasa składowania: 3 - Flammable liquids
• wgk: WGK 1
• flash_point_f: 55.4 °F
• flash_point_c: 13 °C