H0879

Hexamethonium bromide

nAChR antagonist

• Synonim(y): Hexane-1,6-bis(trimethylammonium bromide), N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide
• Wzór liniowy: (CH₃)₃N(Br)(CH₂)₆N(Br)(CH₃)₃
• Numer CAS: 55-97-0
• Masa cząsteczkowa: 362.19
• NACRES: NA.77
• PubChem Substance ID: 24278459
• UNSPSC Code: 12352200
• EC Number: 200-249-7
• MDL number: MFCD00011787
• Beilstein/REAXYS Number: 3715749

Właściwości

• Nazwa produktu: Hexamethonium bromide,
• Quality Segment: 200
• mp: 282-285 °C (dec.)
• SMILES string: [Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C
• InChI: 1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
• InChI key: FAPSXSAPXXJTOU-UHFFFAOYSA-L
• Gene Information: human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Opis

Application

Hexamethonium bromide has been used:

• as an autonomic ganglia-blocking agent to study its effects on whisker movement in rats[1]
• as a nicotinic receptor antagonist to study its effects on antigen-induced arthritis (AIA) progression in mice[2]
• as a non-selective ganglionic nicotinic acetylcholine receptor (nAChR) antagonist to study its effects on cytisine-induced autonomic cardiovascular responses in mice[3]

Biochem/physiol Actions

Hexamethonium bromide is a nicotinic acetylcholine receptor (nAChR) antagonist.[4] It preferentially blocks nicotinic receptors at autonomic ganglia. It can cross the blood-brain barrier only at high doses.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)