F8304

Flavoxate hydrochloride

≥98% (HPLC), solid

• Synonim(y): 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040
• Wzór empiryczny (zapis Hilla): C₂₄H₂₅NO₄ · HCl
• Numer CAS: 3717-88-2
• Masa cząsteczkowa: 427.92
• NACRES: NA.77
• PubChem Substance ID: 24724484
• UNSPSC Code: 12352200
• EC Number: 223-066-4
• MDL number: MFCD00072099
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• InChI: 1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
• InChI key: XOEVKNFZUQEERE-UHFFFAOYSA-N
• SMILES string: Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: ~6.6 mg/mL
• originator: Johnson & Johnson
• Gene Information: human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622)

Opis

Biochem/physiol Actions

Flavoxate, a flavone derivative[1] and a tertiary-amine antimuscarinic[2] possess antispasmodic properties.[2] It is a strong smooth muscle relaxant[1] that selectively acts on the pelvic region[3] and is used in the symptomatic treatment of overactive bladder (OAB)[1] and incontinence.[2] Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues.[1] It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder.[1] Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.[3]

L-type Ca²⁺ (Ca_v1.2) channel inhibitor

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H335
• pcodes: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Oral - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves