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F7804

Fascaplysin chloride hydrate

Name: Fascaplysin chloride hydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonim(y):

12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b′]diindol-5-ium chloride, Fascaplysine hydrate

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About This Item

Wzór empiryczny (zapis Hilla):

C₁₈H₁₁ClN₂O · xH₂O

Numer CAS:

114719-57-2

Masa cząsteczkowa:

306.75 (anhydrous basis)

Numer MDL:

MFCD09752600

Kod UNSPSC:

12352200

Próba

≥98% (HPLC)

Postać

solid

kolor

brick red

rozpuszczalność

H₂O: <2 mg/mL
DMSO: ~20 mg/mL

temp. przechowywania

2-8°C

ciąg SMILES

[Cl-].[H]O[H].O=C1c2ccccc2-[n+]3ccc4c([nH]c5ccccc45)c13

InChI

1S/C18H10N2O.ClH.H2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;;/h1-10H;1H;1H2

Klucz InChI

WPIOPGXRERNYSI-UHFFFAOYSA-N

Działania biochem./fizjol.

Originally isolated from the marine sponge Thorectandra sp., fascaplysin chloride is a selective, potent inhibitor of cyclin dependent kinase 4/cyclin D1 (IC₅₀ = 0.35 μM). It is significantly less selective for Cdk6/D1 (IC₅₀ = 3.4 μM) and not selective for the other Cdks and tyrosine kinases.

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Piktogramy

GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H315,H319,H335

Zwroty wskazujące środki ostrożności

P261 - P305 + P351 + P338

Klasyfikacja zagrożeń

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product.

R Soni et al.

Biochemical and biophysical research communications, 275(3), 877-884 (2000-09-07)

Small chemical molecules that interfere with biological proteins could be useful for gaining insight into the complex biochemical processes in mammalian cells. Cdk4 is a key protein whose activity is required not only for emergence of cells from quiescence but

Inhibition of cancer cell growth by cyclin dependent kinase 4 inhibitors synthesized based on the structure of fascaplysin.

Sachin Mahale et al.

Bioorganic chemistry, 34(5), 287-297 (2006-08-15)

Tryptamine derivatives, a new structural class of cyclin dependent kinase 4 inhibitors, have been identified during extensive biological screening of synthetic molecules. The molecules were synthesized based on the structure of fascaplysin, which is not only a specific inhibitor of

New fascaplysin-based CDK4-specific inhibitors: design, synthesis and biological activity.

Carine Aubry et al.

Chemical communications (Cambridge, England), (15)(15), 1696-1697 (2004-07-28)

The first biologically active non-planar analogues of the toxic anti-cancer agent, fascaplysin, have been produced; we present the design, synthesis and biological activity of three tryptamine derivatives.

[Physiological activity of fascaplisine--an unusual pigment from tropical sea fishes].

A M Popov et al.

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 36(1), 12-14 (1991-01-01)

Various aspects of the physiological activity of fascaplysine, a pigment from tropic sea sponges, were studied. One of the fragments of the chemical structure of the pigment is the indole ring. Ehrlich tumor cells, murine lymphocytes and erythrocytes were used

Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.

Jing Lin et al.

Cancer chemotherapy and pharmacology, 59(4), 439-445 (2006-07-04)

This study was to evaluate the correlation of two important strategies, namely, cell cycle proliferation arrest and anti-angiogenesis. We chose fascaplysin, a marine natural product with selective CDK4 selective inhibition activity, to study its potential anti-angiogenesis effects in vivo and

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