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Key Documents
F0176
Anti-FLI-1 antibody produced in sheep
fractionated antiserum, buffered aqueous solution
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About This Item
Numer MDL:
Kod UNSPSC:
12352203
pochodzenie biologiczne
sheep
białko sprzężone
unconjugated
forma przeciwciała
fractionated antiserum
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 52 kDa
reaktywność gatunkowa
human, mouse
metody
western blot: suitable using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
informacje o genach
human ... FLI1(2313)
mouse ... Fli1(14247)
Immunogen
GST fusion protein of the N-terminus of Fli-1 corresponding to amino acids 1-239.
Zastosowanie
Anti-FLI-1 antibody produced in sheep is suitable for western blotting using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
Działania biochem./fizjol.
Friend leukemia integration 1 transcription factor (FLI1) is a protein that is encoded by the FLI1 gene in humans and is a member of Ets transcription factor family. It is a proto-oncogene and located on human chromosome 11q23-24. FLI1 may be involved in human sarcomas, leukemias and lymphomas. It may play an important role in the posttranscriptional regulation of the Fli-1 transcript. Alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies. It is a novel ETS transcription factor involved in gene fusions in prostate cancer.
Postać fizyczna
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
V N Rao et al.
Oncogene, 8(8), 2167-2173 (1993-08-01)
Three of the ets oncogene superfamily members v-ets, Spi-1/PU.1 and Fli-1, have been shown to be directly involved in retroviral-mediated acute erythroleukemias. The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia
Steven M Kornblau et al.
Blood, 118(20), 5604-5612 (2011-09-16)
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression
Paula Paulo et al.
Genes, chromosomes & cancer, 51(3), 240-249 (2011-11-15)
To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes, we analyzed 200 prostate carcinomas (PCa) with TaqMan low-density arrays (TLDAs), followed by selective analyses with fluorescence in situ hybridization (FISH), RT-PCR, and sequencing. Besides confirming
D D Prasad et al.
Cancer research, 52(20), 5833-5837 (1992-10-15)
Three ets family members, v-ets, spleen focus forming virus proviral integration 1/Pu.1, and Friend leukemia integration 1 (Fli-1), were shown to be involved in retroviral mediated acute leukemias suggesting that ets family members play a crucial role in transformation. Mouse
V Baud et al.
Genomics, 11(1), 223-224 (1991-09-01)
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie
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